2016–2022 Lexus RX350 repair guides

Filmed on 2016 and 2021 cars, these guides cover the 2016, 2017, 2018, 2019, 2020, 2021 and 2022 Lexus RX350. The fourth generation shares its body, filters, wipers, lighting and climate system across the run, so the steps are the same on the 2020 facelift cars as on the early ones. Where the 2016 and 2021 differ (mostly the center console and infotainment), the guide says so.

The RX350L three-row and RX450h hybrid share most of these jobs. Where a job differs from the 2010–2015 car, the guide says so.

2016–2022 RX350

Climate & HVAC

2016–2022 4 min

Climate & HVAC

2016 Lexus RX350 AC Recharge (Adding R-134a Refrigerant Yourself)

The dealership flagged a low AC charge on a 2016 Lexus RX350 during a routine service. Here's how to top off the R-134a refrigerant yourself with a self-gauging DIY recharge kit.

Moderate

2016–2022 RX350

Lights

2016–2022 9 min

Lights

2016 Lexus RX350 Tail Light Water/Condensation Fix

Water and condensation building up inside a 2016 Lexus RX350 tail light housing? Here's how to open it up, find where water is getting in, and drain it before it reaches the circuit board.

Moderate

2016–2022 RX350

Wipers & Filters

2016–2022 4 min

Wipers & Filters

2021 Lexus RX350 Cabin Filter, Engine Air Filter & Wiper Replacement (Under $30)

Replace the cabin air filter, engine air filter, and wiper blades on a 2021 Lexus RX350 yourself in under 5 minutes for under $30 total in parts.

Easy Under $30 total

2016–2022 5 min

Wipers & Filters

2016 Lexus RX350 Rear Wiper Replacement (Push-Button Release, Not the 2010's Trick)

The 2016 Lexus RX350 swapped to a push-button-and-slide wiper release — different from the hidden-under-the-spoiler trick the 2010 RX350 needs. Here's how the 2016 rear wiper actually comes off.

Easy

2016–2022 11 min

Wipers & Filters

2016 Lexus RX350 Air Filter Comparison (OEM vs Aftermarket, Cabin & Engine)

OEM Lexus air filters cost a lot more than aftermarket — is the difference worth it? A side-by-side comparison of cabin and engine air filters on a 2016 RX350, plus how to replace both.

Easy ~$16 (aftermarket pair)…

2016–2022 RX350

Audio & Interior

2016–2022 19 min

Audio & Interior

2021 Lexus RX350 Center Console/Radio Removal (AC Vent Access)

How to pull the center console and radio unit on a 2021 Lexus RX350 to reach a broken AC vent register — the same access path used to add Apple CarPlay wiring or an amplifier.

Advanced

2010–2015 · 2016–2022 2 min

Audio & Interior

Best Lexus RX350 Audio EQ Settings (2010 & 2016)

Dial in the factory head unit's EQ to get the most out of the stock 2010 RX350 system and the upgraded 2016 system — the exact treble, mid, and bass settings used for each.

Easy

2016–2022 21 min

Audio & Interior

2016 Lexus RX350 Dash Speaker Upgrade (Get the Missing Tweeter Highs Back)

Lexus dropped the front-door tweeter on the 2016 RX350, dulling the highs versus the 2010. Swap just the two dash speakers for a 4-inch coaxial set with a built-in tweeter to bring the crisp top end back — here's the full DIY install.

Moderate ~$79 for the pair (~$40…

2010–2015 · 2016–2022 6 min

Audio & Interior

Lexus RX350 Bluetooth Setup Tips (2010–2015 vs 2016+)

The 2010-2015 RX350 needs phone pairing and audio Bluetooth registered separately, in a specific order, or the connection fights itself. The 2016+ head unit does both in one step.

Moderate

Also applies to the 2016–2022

Guides that cover every RX350

All years 2 min

Engine & Electrical

Lexus RX350 Smart Key Battery Replacement (2 Minutes, No Tools)

Smart key gone completely dead after sitting unused? Pop the shell open and swap in a fresh CR1632 battery — no reprogramming needed.

Easy A few dollars for the ba…